The Role of Chemometrics in Establishing PAT Prediction Models for Analytical Concentration Determination
DOI: 10.62178/sst.004.008
Abstract
The implementation of Process Analytical Technologies (PAT) has not been possible without a symbiotic relationship with chemometrics – multivariate data analysis and modelling. This article complements the context for this issue of SAMPLING SCIENCE and TECHNOLOGY (SST), ‘The PAT issue’, by introducing a compact brief of chemometrics: defined as the extraction of information from chemical data for the purposes of making informed decisions, especially when integrated with PAT, where quality decisions are made in real-time on the current state of the process. Using predictive chemometric models, changes can be made to the process so as to minimise the risk of deviations and out-of-specification (OOS) material.
Published in Issue 4 · December 2025
Citing this article
Swarbrick, B. (2025). The Role of Chemometrics in Establishing PAT Prediction Models for Analytical Concentration Determination. Sampling Science & Technology, December 2025(4), 83-93. https://doi.org/10.62178/sst.004.008
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